Automatic PET-CT Image Registration Method Based on Mutual Information and Genetic Algorithms

Hybrid PET/CT scanners can simultaneously visualize coronary artery disease as revealed by computed tomography (CT) and myocardial perfusion as measured by positron emission tomography (PET). Manual registration is usually required in clinical practice to compensate spatial mismatch between datasets. In this paper, we present a registration algorithm that is able to automatically align PET/CT cardiac images. The algorithm bases on mutual information (MI) as registration metric and on genetic algorithm as optimization method. A multiresolution approach was used to optimize the processing time. The algorithm was tested on computerized models of volumetric PET/CT cardiac data and on real PET/CT datasets. The proposed automatic registration algorithm smoothes the pattern of the MI and allows it to reach the global maximum of the similarity function. The implemented method also allows the definition of the correct spatial transformation that matches both synthetic and real PET and CT volumetric datasets

Characterization of social behavior in a group of domestic donkeys (Equus asinus)

Although the popularity of domestic donkeys is increasing, the scientific literature on their behavior is still limited. This study investigated the social behavior of a group of 13 donkeys (10 females, 3 geldings, aged 3-13 years) stabled in an Animal Assisted Interventions facility in the North of Italy. Our first aim was to assess the distribution of donkeys’ intraspecific social behaviors during daytime and the second aim was to characterize affiliative and agonistic social interactions during peak activity times. Social behaviors were expressed more between 8 and 9 AM than the rest of daytime, mainly reflecting the expression of affiliative behavior. The latter consisted mostly of proximity (55.0% of all affiliative) and following (29.2%). In most cases affiliative behavior was expressed within preferential dyads, composed of either a mother and her offspring or two adult donkeys. This supports the idea that dyadic relationships are a predominant feature of the social organization of the species. However, dyadic interactions were not observed in the oldest sub-adults, suggesting that social preferences undergo a change around the time donkeys reach full growth. Agonistic behaviors were much less common than affiliative ones. The most expressed agonistic behavior was threat (51%), followed by displacement and bite (both 18.5%). They were less expressed by donkeys who were part of an affiliative pair, suggesting that limited expression of agonistic behavior is associated with an actual change in social preferences, not a mere consequence of fewer occasions of conflict over resources. While the study has limitations, the results provide insight into the social behavior of domestic donkeys which could represent a starting point for further research as well as relevant information for donkeys farming

A modular path planning solution for Wire + Arc Additive Manufacturing

Wire + Arc Additive Manufacturing (WAAM) has proven its capability to build medium to large metallic parts thanks to its high-rate deposition and its potentially unlimited build volume. Moreover, the low-cost equipment and the ability to deposit various metals make WAAM a strong candidate to become a standard industrial process. However, like all Additive Manufacturing (AM) technologies, the key to manufacturing suitable parts lies in the generation of an optimised path that guarantees a uniform defect-free deposition. Most AM technologies have been able to use traditional path strategies derived from CNC machining, but the specificities inherent to the arc deposition make the use of those solutions unreliable across a variety of topologies. Nevertheless, studies have shown that superior results can be achieved by using a feature-based design approach, but developing a path strategy for each new geometry would be a very time-consuming task. Therefore, this paper introduces the Modular Path Planning (MPP) solution that aims to incorporate the modularity of feature-based design into the traditional layer-by-layer strategy. By dividing each layer into individual deposition sections, this method allows users to adapt the path planning to the targeted geometry allowing the construction of a wide variety of complex geometries. This paper also proposes a software implementation that limits user interventions and reduces user inputs to basic CAD modelling operations. Moreover, the MPP has been compared to a traditional path planning solution and used to build a complex part for industry

Microstructure and thermal properties of unalloyed tungsten deposited by wire + Arc Additive Manufacturing

Tungsten is considered as one of the most promising materials for nuclear fusion reactor chamber applications. Wire + Arc Additive Manufacturing has already demonstrated the ability to deposit defect-free large-scale tungsten structures, with considerable deposition rates. In this study, the microstructure of the as-deposited and heat-treated material has been characterised; it featured mainly large elongated grains for both conditions. The heat treatment at 1273 K for 6 h had a negligible effect on microstructure and on thermal diffusivity. Furthermore, the linear coefficient of thermal expansion was in the range of 4.5 × 10−6 μm m−1 K−1 to 6.8 × 10−6 μm m−1 K−1; the density of the deposit was as high as 99.4% of the theoretical tungsten density; the thermal diffusivity and the thermal conductivity were measured and calculated, respectively, and seen to decrease considerably in the temperature range between 300 K and 1300 K, for both testing conditions. These results showed that Wire + Arc Additive Manufacturing can be considered as a suitable technology for the production of tungsten components for the nuclear sector

Grain refinement in an unalloyed tantalum structure by combining Wire+Arc additive manufacturing and vertical cold rolling

Components manufactured via Wire + Arc Additive Manufacturing are usually characterised by large columnar grains. This can be mitigated by introducing in-process cold rolling; in fact, the associated local plastic deformation leads to a reduction of distortion and residual stresses, and to microstructural refinement. In this research, inter-pass rolling was applied with a load of 50 kN to a tantalum linear structure to assess rolling’s effectiveness in changing the grain structure from columnar to equiaxed, as well as in refining the grain size. An average grain size of 650 μm has been obtained after five cycles of inter-pass rolling and deposition. When the deformed layer was reheated during the subsequent deposition, recrystallisation occurred, leading to the growth of new strain-free equiaxed grains. The depth of the refined region has been characterised and correlated to the hardness profile developed after rolling. Furthermore, a random texture was formed after rolling, which should contribute to obtaining isotropic mechanical properties. Wire + Arc Additive Manufacture demonstrated the ability to deposit sound refractory metal components and the possibility to improve the microstructure when coupled with cold inter-pass rolling

Effect of shielding gas composition and welding speed on autogenous welds of unalloyed tungsten plates

Tungsten usually exhibits poor weldability and marked brittleness at room temperature. This causes tungsten welds to be affected by the evolution of cracks along the weld bead, which can be eliminated by using a pre-heating step to reduce thermal straining. In this study, based on the tungsten inert gas welding process, a working envelope, focussed on varying welding speed and five different shielding gas mixtures of argon and helium, has been defined with the view of producing crack-free autogenous welds. The bead appearance and the microstructure of the different welds were correlated to the welding parameters, whose main effects have been analysed. Welding defects such as humping occurred when using gas mixtures with relatively low content of helium, and when using relatively high welding speeds. Crack-free autogenous welds have been produced without pre-heating when using a high content of helium and relatively low welding speeds. Thus, this study has demonstrated that a helium-rich shielding gas is required for welding thick tungsten plates. Moreover, the low thermal shock induced by the process, coupled with the purity of the tungsten plates used, strongly contributed to avoid the occurrence of any crack

Microstructure, hardness and mechanical properties of two different unalloyed tantalum wires deposited via wire + arc additive manufacture

An innovative way of producing large-scale unalloyed tantalum parts, based on the Wire + Arc Additive Manufacturing process, has been developed in this study. Two different unalloyed tantalum wires have been used to deposit 200-mm-long structures in tantalum. The effect of the wire chemistry on microstructure, hardness, porosity, mechanical properties and strain localisation has been investigated. The deposits showed high integrity and excellent mechanical properties, with yield strength, ultimate tensile strength and elongation as high as 234 MPa, 261 MPa, and 36%, respectively. Indeed, yield strength was higher than commercially available tantalum, even though, in this study, the grains were large and had a high aspect ratio. Wire + Arc Additive Manufacture has clearly shown the potential to produce tantalum components with relatively low cost and reduced lead time, thus offering a new robust and viable manufacturing route